Transcription factor condensates: Preventing aggregation by DNA binding.
editorial · Level V
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- Record sourced from PubMed, PMID 40446356.
- Also identified by DOI 10.1016/j.cell.2025.04.034.
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Abstract
Transcription factors can form nuclear condensates at genomic sites, and condensates are thought to enhance transcriptional activity. In this issue of Cell, Saad et al. suggest that DNA binding prevents rather than facilitates condensate formation of particularly aggregation-prone transcription factors.
Medical subject headings
- Transcription Factors
- DNA