ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40446357.
- Also identified by DOI 10.1016/j.cell.2025.04.033 and PMC identifier 12309789.
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Abstract
Red blood cell (RBC) lysis can cause morbidity and mortality. However, the molecular mechanisms underlying RBC lysis are not fully characterized, limiting therapeutic options. In this issue of Cell, Chen et al. identify a crucial role for the NLRP3-ASC-caspase-8 complex in driving programmed lytic cell death in RBCs.
Medical subject headings
- Caspase 8
- Erythrocytes