Genetic compensation response contributes to Pleurodeles waltl limb regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40450023.
- Also identified by DOI 10.1038/s41536-025-00417-y and PMC identifier 12126524.
- Licence recorded as CC BY-NC-ND.
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Abstract
Hippo-Yap/Taz pathway is essential for tissue regeneration in multiple species. However, we found that in the highly regenerative salamanders, Yap knockout does not compromise the limb regeneration due to genetic compensation response (GCR). Specifically, the mutated Yap locus derived non-sense mRNA, which was recognized by UPF3A to instruct compensatory Taz induction. Blocking Yap mRNA or protein indeed inhibits regeneration. GCR could be utilized to maintain the robustness of limb regeneration.