Therapeutic B cell depletion identifies immunoregulatory networks.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40454471.
- Also identified by DOI 10.1172/JCI189442 and PMC identifier 12126224.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
B cell depletion is a highly effective therapy in multiple sclerosis (MS), reducing inflammation and restoring immune balance. In this issue of the JCI, Wei et al. used single-cell RNA-Seq and flow cytometry, identifying the comprehensive effects of B cell depletion on the immune response, including an increase in antiinflammatory cerebrospinal fluid macrophages and elevated TNF-α expression by peripheral CD16+ monocytes. The authors also detected shifts in T cell populations that resulted in reduced myelin-reactive CD4+ T cells and the expansion of TIGIT+ Tregs. The findings uncover immunoregulatory mechanisms and suggest therapeutic strategies for MS and other autoimmune disorders.
Medical subject headings
- B-Lymphocytes
- Multiple Sclerosis
- Lymphocyte Depletion
- T-Lymphocytes, Regulatory