Confirmation of HLA-II associations with TB susceptibility in admixed African samples.
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Where this comes from
- Record sourced from PubMed, PMID 40458991.
- Also identified by DOI 10.7554/eLife.99200 and PMC identifier 12133154.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Previously, the International Tuberculosis Host Genetics Consortium (ITHGC) demonstrated the power of large-scale GWAS analysis across diverse ancestries in identifying tuberculosis (TB) susceptibility loci (Schurz et al., 2024). Despite identifying a significant genetic correlate in the human leukocyte antigen (HLA)-II region, this association did not replicate in the African ancestry-specific analysis, due to small sample size and the inclusion of admixed samples. Our study aimed to build upon the findings from the ITHGC and identify TB susceptibility loci in an admixed South African cohort using the local ancestry allelic adjusted association (LAAA) model. We identified a suggestive association peak (<i>rs3117230</i>, p-value = 5.292 × 10<sup>-6</sup>, OR = 0.437, SE = 0.182) in the <i>HLA-DPB1</i> gene originating from KhoeSan ancestry. These findings extend the work of the ITHGC, underscore the need for innovative strategies in studying complex admixed populations, and confirm the role of the HLA-II region in TB susceptibility in admixed South African samples.
Medical subject headings
- Genetic Predisposition to Disease
- Tuberculosis
- Black People
- HLA-DP beta-Chains