Differentiating Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses Between Infection and Vaccination: Challenges for Epidemiological Research.

Nayagam, Sunav N; Coote, William; Carroll, Matthew T C; Toh, Zheng Quan; Licciardi, Paul V; Abramson, Michael J; Walker-Bone, Karen; Lane, Tyler J · J Infect Dis · 2025

expert_opinion · Level V

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Abstract

Some common coronavirus disease 2019 (COVID-19) vaccines elicit antibody responses that most serological tests are unable to differentiate from an infection response. This presents a challenge for COVID-19 epidemiology and serosurveys. In this perspective, we examine the potential scale of this problem.

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