GES-66: Characterization of a New β-Lactamase Gene Variant Detected in Klebsiella pneumoniae.
basic_science · Level V
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- Record sourced from PubMed, PMID 40465844.
- Also identified by DOI 10.1093/infdis/jiaf302.
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Abstract
Guiana extended-spectrum (GES) β-lactamase enzymes have been traditionally classified as extended-spectrum β-lactamases; however, there are increasing reports of GES variants with carbapenemase activity. This study reports the first characterization of GES-66, a GES type not previously described, detected in a pair of sequence type 252 Klebsiella pneumoniae isolates from clinical and environmental sources in Argentina. GES-66 differs from GES-5 by a single amino acid substitution, E104K, while retaining the G170S alteration. Our data support that GES-66 has carbapenemase activity.
Medical subject headings
- beta-Lactamases
- Klebsiella pneumoniae
- Bacterial Proteins