Time to exercise! Boosting exercise performance via AMPK signaling.

Collet, Tinh-Hai; Dibner, Charna · Cell Metab · 2025

other · Level V

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Abstract

Body physiology follows the daily rhythm driven by the circadian system, which underlies the emerging concept of chrono-medicine. In this issue, Chen et al.<sup>1</sup> report that feeding timing modulates adipocyte AMP-activated protein kinase (AMPK) α2 signaling to enhance exercise performance in mice, paving the way for chronotherapeutic approaches of AMPK activators such as metformin.

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