CROSsing the Rubicon: Brainstem peroxide levels drive sleep-wake dynamics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40466624.
- Also identified by DOI 10.1016/j.cmet.2025.05.005.
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Abstract
A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.<sup>1</sup> provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.
Medical subject headings
- Sleep
- Wakefulness
- Brain Stem
- Peroxides