GLP-1RAs for peripheral artery disease: A remarkable STRIDE in the right direction.

Verma, Subodh; Hess, David A · Cell Metab · 2025

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Abstract

With the rising prevalence of T2D worldwide, peripheral artery disease (PAD) now affects >230 million individuals globally. In the recent STRIDE trial, Bonaca et al.<sup>1</sup> demonstrated that semaglutide improved walking capacity and hemodynamic parameters and slowed PAD progression in patients with T2D. These results reveal an unanticipated vasculoprotective benefit of GLP-1RAs.

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