Monoclonal gammopathy of cutaneous significance.

Abstract

Monoclonal gammopathies are strongly associated with several dermatologic diseases. Classification of the underlying hematologic disorder often impacts management; in many cases, patients with a gammopathy-related skin disease are diagnosed with monoclonal gammopathy of undetermined significance and monitored for progression to multiple myeloma. Herein we discuss the concept of "monoclonal gammopathy of cutaneous significance", a paraproteinemia with serious cutaneous sequelae which may warrant comanagement with hematology and treatment that addresses the underlying immunoglobulin- or plasma cell disorder. This article provides a review of monoclonal gammopathy of cutaneous significance clinical manifestations, diagnosis, as well as emerging data on targeted therapies.