Neurosteroid treatment of postpartum depression and beyond.

Deligiannidis, Kristina M; Meltzer-Brody, Samantha · Br J Psychiatry · 2025

review · Level V

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Abstract

Depression occurring during pregnancy or after delivery is one of the most common complications of childbirth and is associated with maternal morbidity and mortality. Here we review the breakthrough development of the first neuroactive steroid-based antidepressants approved for postpartum depression in the USA and their potential in other psychiatric illnesses.

Medical subject headings