Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 40471829.
- Also identified by DOI 10.14309/ajg.0000000000003574.
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Abstract
Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD). We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers. CD-associated SBA showed a significantly ( P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA. Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.
Medical subject headings
- Celiac Disease
- Adenocarcinoma
- Lymphoma, T-Cell
- Intestinal Neoplasms
- Jejunal Neoplasms
- Intestine, Small