Deletion of Galectin-3 Renders Mice Less Susceptible to Candida auris Skin Infection by Enhancing Antifungal Activity of Neutrophils.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40473589.
- Also identified by DOI 10.1093/infdis/jiaf300 and PMC identifier 12718018.
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Abstract
Candida auris is an emerging multidrug-resistant fungal pathogen that uniquely colonizes the skin. The factors regulating C auris colonization are poorly understood. In this study, we examined the role of galectin-3 during C auris skin infection. We found that deletion of galectin-3 enhances the antifungal activity of neutrophils and increases resistance to C auris skin infection. Mechanistically, galectin-3 negatively regulates GLUT4 expression, glucose uptake, reactive oxygen species production, and fungal killing by neutrophils. Collectively, our findings uncover a detrimental role for galectin-3 in neutrophil-mediated defense against C auris.
Medical subject headings
- Neutrophils
- Galectin 3
- Candida auris
- Candidiasis, Cutaneous