Revolutionizing Thyroid Cancer Treatment: Restoring Radioiodine Avidity After PRRT-A Case Series.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 40474371.
- Also identified by DOI 10.1097/RLU.0000000000005809.
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Abstract
Four cases of thyroid cancer became radioiodine-refractory following conventional treatments. While no RAI-avid lesion was noticed in the initial whole-body radioiodine scan (WBIS), their metastatic foci had trace avidity. They were diagnosed as TENNIS; 2 cycles of peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTA-TATE were administrated, then the thyroglobulin levels dropped significantly. The PRRT was discontinued, and the diagnostic WBIS was repeated. Surprisingly, the scan revealed increased considerable tracer uptake in the metastatic foci. This restoration of radioiodine uptake seems to occur due to PRRT-induced tumor irradiation. Suggesting PRRT may serve as a potential re-differentiation strategy in TENNIS.
Medical subject headings
- Thyroid Neoplasms
- Iodine Radioisotopes
- Receptors, Peptide