Different Appearances of Esophageal Squamous Cell Carcinoma in 18 F-PSMA PET/CT Versus 18 F-FDG PET/CT.

Wang, Jiaqiong; Li, Yi; Doss, Mohan; Yu, Jian Q Michael · Clin Nucl Med · 2025

case_report · Level V

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Abstract

An 81-year-old man with a history of prostate cancer, status post radiation therapy, was referred for a prostate-specific membrane antigen (PSMA) PET/CT scan. Fluorine-18 DCF-Pyl (Pylarify) PSMA PET/CT showed focal increased radiotracer uptake at the right prostate and bilateral iliac chain metastatic lymph nodes. The same PSMA PET/CT showed focal increased radiotracer uptake at the junction of the mid to lower esophagus. 18 F-FDG PET/CT identified a large hypermetabolic esophageal mass in the mid to lower esophagus, showing a greater extent of esophageal disease than the PSMA PET/CT. An endoscopic biopsy confirmed poorly differentiated esophageal squamous cell carcinoma.

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