Daily Carbohydrate Entries and Glycemic Outcomes Following Automated Insulin Delivery System Initiation in Youth With Type 1 Diabetes: A Real-World Multinational Longitudinal Study.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 40478457.
- Also identified by DOI 10.2337/dc25-0283.
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Abstract
To assess the association between daily carbohydrate (CHO) entries and glycemic outcomes in youth with type 1 diabetes after automated insulin delivery (AID) initiation in real-life settings. In this longitudinal, multinational observational study, 347 young individuals (7-21 years old) with type 1 diabetes for >1 year were followed for >6 months after AID initiation. Clinical data, including daily and overall continuous glucose monitoring-based time in range (TIR) (70-180 mg/dL), time in tight range (TITR) (70-140 mg/dL), and CHO entry metrics, were evaluated. Day-to-day variability in CHO entries was negatively associated with overall TIR (P < 0.001) and TITR (P < 0.001). Higher deviation in daily CHO entry was associated with lower daily TITR and TIR (both P < 0.001). Overall TIR and TITR after AID initiation were 75.0% and 50.3%, respectively. Variability in CHO entries is associated with lower TIR, emphasizing the importance of consistent premeal bolus routine when using AID.
Medical subject headings
- Diabetes Mellitus, Type 1
- Insulin
- Blood Glucose
- Insulin Infusion Systems
- Hypoglycemic Agents
- Dietary Carbohydrates