From genes to geometry: Controlling embryo models by programming genomic activation.
basic_science · Level V
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- Record sourced from PubMed, PMID 40480203.
- Also identified by DOI 10.1016/j.stem.2025.04.013.
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Abstract
Embryo-like models derived from stem cells have emerged as powerful tools to study early development. In this issue, Lodewijk et al.<sup>1</sup> demonstrate that activating just two enhancers via CRISPR activation (CRISPRa) in mouse embryonic stem cells (ESCs) can drive self-organization into structured embryo-like models, offering a genome-driven approach in stem cell and developmental biology.
Medical subject headings
- Embryo, Mammalian
- Genome
- Models, Biological