On-demand microglia deliver the therapeutic payload in Alzheimer's disease.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40480204.
- Also identified by DOI 10.1016/j.stem.2025.05.003.
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Abstract
In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloid burden, neuronal damage, and inflammation in an Alzheimer's disease (AD) mouse model.<sup>1</sup> These findings establish a cell-based strategy to treat neurological diseases.
Medical subject headings
- Alzheimer Disease
- Microglia