Complexity within simplicity: Exploring the multifactorial nature of sickle cell disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40482641.
- Also identified by DOI 10.1016/j.ajhg.2025.05.008 and PMC identifier 12256871.
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Abstract
Sickle cell disease, though monogenic, exhibits complex clinical variability driven by genetic, epigenetic, and environmental factors. This commentary highlights advances in precision therapies and underscores the urgent need for equitable access, global collaboration, and personalized approaches to address the significant health disparities impacting individuals with sickle cell disease worldwide.
Medical subject headings
- Anemia, Sickle Cell
- Multifactorial Inheritance