Bioenergetic stress potentiates antimicrobial resistance and persistence.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40490453.
- Also identified by DOI 10.1038/s41467-025-60302-6 and PMC identifier 12149317.
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Abstract
The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species (ROS) formation. Here, we investigate the effects of 'bioenergetic stress', induced by constitutive hydrolysis of ATP and NADH, on antibiotic efficacy in Escherichia coli. We show that bioenergetic stress potentiates the evolution of antibiotic resistance via enhanced ROS production, mutagenic break repair, and transcription-coupled repair. In addition, bioenergetic stress potentiates antibiotic persistence via the stringent response. We propose a model in which the balance between ATP consumption versus production regulates antibiotic resistance and persistence.
Medical subject headings
- Escherichia coli
- Energy Metabolism
- Anti-Bacterial Agents
- Stress, Physiological
- Drug Resistance, Bacterial