177 Lutetium-PSMA Therapy in a Patient With Concurrent Prostate Cancer and Renal Cell Carcinoma.
case_report · Level V
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- Record sourced from PubMed, PMID 40494366.
- Also identified by DOI 10.1097/RLU.0000000000005964.
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Abstract
A 77-year-old man with metastatic prostate cancer presented with debilitating bone pain and rising PSA despite anti-androgen therapy. 68 Ga-PSMA PET/CT scan revealed widespread PSMA-positive bone metastases with an incidental PSMA-avid renal mass, later confirmed as renal cell carcinoma (RCC). The patient received four cycles of 177 Lu-PSMA-617, which resulted in complete pain resolution, marked improvement in bone metastases, and PSA reduction; while no change in the renal mass is noted. Despite the beneficial effects of 177 Lu-PSMA therapy in metastatic prostate cancer, its efficacy in nonprostatic malignancies is under investigation. In this case, 177 Lu-PSMA-617 did not show remarkable therapeutic efficiency in RCC.
Medical subject headings
- Prostatic Neoplasms
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Lutetium
- Radioisotopes
- Heterocyclic Compounds, 1-Ring
- Dipeptides