18 F-FAPI PET/CT in An Adult Orbital-Nasal Alveolar Rhabdomyosarcoma: Comparisons With 18 F-FDG PET/CT.

Li, Hui; Suo, Lingge; Zhou, Jichao; Zhang, Weifang; Wang, Yi · Clin Nucl Med · 2025

case_report · Level V

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Abstract

Rhabdomyosarcoma is common in children and adolescents but rare in adults. Here, we presented a 41-year-old man with orbital-nasal alveolar rhabdomyosarcoma who underwent both 18 F-FDG and 18 FAl-NOTA-FAPI PET/CT. 18 FAl-NOTA-FAPI PET/CT showed intense uptake in the primary lesion and regional metastatic lymph nodes with an excellent tumor-to-background ratio, compared with the mild to moderate uptake on 18 F-FDG PET/CT. In addition, 18 FAl-NOTA-FAPI PET/CT detected bone metastases that were not identified by 18 F-FDG PET/CT, which altered the patient's tumor stage and treatment strategy. This case suggests that 18 FAl-NOTA-FAPI PET/CT maybe superior to 18 F-FDG PET/CT in the assessment of adult orbital-nasal alveolar rhabdomyosarcoma.

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