Incidental Detection of Poorly Differentiated Neuroendocrine Carcinoma in Penile Urethra on 18 F-Fluciclovine PET/CT.

Wang, Shih-Hao; Wang, Lien-Yen; Li, Chia-Ying; Shih, Hung-Jen; Lin, Chun-Yi · Clin Nucl Med · 2025

case_report · Level V

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Abstract

We report the case of an 88-year-old man with suspected biochemical recurrence of prostate cancer, in whom 18 F-fluciclovine PET/CT was performed in the context of rising prostate-specific antigen (PSA) levels. Incidental identification of penile urethral activity was observed. A subsequent urethral biopsy revealed a treatment-related, poorly differentiated neuroendocrine carcinoma of prostatic origin, with metastasis to the penile urethra.

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