Injectable, Solvent Free Strontium Carbonate Poly(Allyl Glycidyl Ether Succinate) Composite Networks for Vertebral Augmentation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40531598.
- Also identified by DOI 10.1002/adhm.202501633 and PMC identifier 12257568.
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Abstract
Vertebral body compression fractures are a major cause of chronic back pain, particularly in older adults. Augmentation is currently performed by injecting a poly(methyl methacrylate) (PMMA) slurry of polymer, monomer, and initiator mixed with barium sulfate (BaSO<sub>4</sub>) into the vertebrae, which then polymerizes in vivo. Herein, a solvent-free polymer system using poly(allyl glycidyl ether succinate) (PAGES) is developed for vertebral augmentation. PAGES crosslinks in situ through thiol-ene click chemistry with a cure time at 37 °C ranging from 17 to 53 min based on degree of polymerization and crosslinker concentration. The addition of SrCO<sub>3</sub> increased the ultimate compressive strength (σ<sub>max</sub>) of the PAGES composite to 4.4 ± 0.4 MPa. Furthermore, SrCO<sub>3</sub> increases osteoblast proliferation and differentiation of mesenchymal stem cells seeded onto the surface of PAGES composite. Finally, the compressive strength of fractured vertebrae is increased in an ex vivo surrogate rabbit model when filled with injected PAGES composite, demonstrating its potential as a bone augmentation material.
Medical subject headings
- Spinal Fractures
- Strontium
- Epoxy Compounds
- Polymers
- Spine