Biodistribution and Radiation Dosimetry for [⁶⁸Ga]Ga-LNTH-1363S, a Probe Targeting Fibroblast Activation Protein α.

Abstract

The objective of this study is to evaluate the PET biodistribution and radiation dosimetry of the fibroblast activation protein (FAP)-targeted tracer [⁶⁸Ga]Ga-LNTH-1363S in cancer patients. <b>Methods:</b> Five patients with oncologic diseases (breast cancer, papillary thyroid carcinoma) were injected intravenously with 153-184 MBq of [⁶⁸Ga]Ga-LNTH-1363S. PET/CT imaging was performed at 10, 60, and 180 min after administration of [⁶⁸Ga]Ga-LNTH-1363S. Normal tissue dosimetry was performed following the MIRD dosimetry formalism. SUV analysis of normal tissues and tumors was performed. <b>Results:</b> The biodistribution of [⁶⁸Ga]Ga-LNTH-1363S demonstrated rapid tumor uptake and efficient clearance from nontarget tissues, resulting in high tumor-to-background ratios at all imaging time points. The kidneys received the highest absorbed dose among normal tissues (0.038 ± 0.01 mGy/MBq), followed by the pancreas and salivary glands. The tumor SUV_max peaked at 10 min after injection (18.6 ± 7.2) and remained high at later time points. No adverse events were observed during follow-up, and the effective dose (0.013 ± 0.002 mSv/MBq) was consistent with other FAP tracers. <b>Conclusion:</b> [⁶⁸Ga]Ga-LNTH-1363S offers favorable dosimetry and biodistribution profiles, comparable with other FAP-targeted tracers.