Membranous Nephropathy and Papillary Thyroid Cancer: A Case Report.

Yogev, David; Dotan, Arad; Bitan, Ohad; Avior, Galit · Laryngoscope · 2025

case_report · Level V

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Abstract

This case report highlights a rare association between membranous nephropathy (MN) and papillary thyroid carcinoma (PTC) in a 66-year-old female with progressive renal dysfunction. Following a confirmed diagnosis of MN with negative phospholipase A2 receptor (PLA2R) staining, imaging revealed a thyroid malignancy, and total thyroidectomy led to clinical improvement, suggesting a paraneoplastic mechanism. This case underscores the importance of oncologic screening in MN patients and the need for further research into the pathophysiological links between MN and thyroid cancer.

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