A microfluidic platform for studying supercritical fluid crystallization and its applications.
basic_science · Level V
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- Record sourced from PubMed, PMID 40539940.
- Also identified by DOI 10.1039/d4lc01032a.
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Abstract
We demonstrate here the development and use of an on-chip crystallization microfluidic device combined with <i>in situ</i> analytical techniques for supercritical antisolvent crystallization. The setup facilitated real-time observation of crystallization events under pressure, giving critical insights into the time-dependent dynamics of the crystallization process. By integrating Raman spectroscopy for continuous monitoring, the system enabled precise control of local species concentrations during diffusion-driven crystallization. The microfluidic platform demonstrated effectiveness in rapid crystal screening and the identification of new co-crystals.