Lenacapavir: a potential game changer for HIV prevention in the Americas, if the game is played equitably.

Cantos, Valeria D; Ramírez, Brenda Crabtree; Kelley, Colleen F; Rio, Carlos Del; Grinsztejn, Beatriz · Lancet Reg Health Am · 2025

expert_opinion · Level V

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Abstract

Lenacapavir, a first in class long-acting capsid inhibitor has near 100% efficacy in preventing HIV. As such, it has the potential to curb the rising HIV incidence in Latin America, a region with stark intra- and inter-country PrEP uptake disparities. In this viewpoint, we summarize the current efforts to scale up lenacapavir access globally and the necessary steps to include Latin America in these endeavours.