An insider's guide to understanding and obtaining an NIH K career development award.

Rockey, Don C; Rhee, Kyu Y; Williams, Christopher S; Vyas, Jatin M; Emala, Charles W; Gallagher, Emily J · JCI Insight · 2025

expert_opinion · Level V

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Abstract

Physician-scientists in academic medical centers require extramural grant support to launch and maintain their research careers. In order to cultivate the next generation of biomedical researchers, including physician-scientists, the NIH supports multiple career development (K series) awards. For many, their first experience in grant writing is composing a career development award (CDA) application. From the applicant's perspective, this process can be difficult. For one, NIH institute-specific differences between the same K mechanism can be confusing. Additionally, the importance of the various elements that make up the K application are frequently misunderstood. Furthermore, many K applications will not be funded on the initial submission; therefore, the need to resubmit an application should not be viewed as a sign of failure, but rather can be viewed as an element of resilience in biomedical research. In this piece, we aim to provide guidance for aspiring K applicants - in particular, from the reviewer perspective - with the intent of making the application process more understandable. We offer dos and don'ts on different components of the K application, advice on when to reach out to a program officer, and tips on resubmission. Our overarching goal is to provide support for prospective K applicants in their effort to obtain a K award. While targeted to K applications, most of the contents of this summary apply to any CDA.

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