Macrophage-Expressed Micropeptide Smim30 Maintains Adipose Tissue Insulin Sensitivity and Safeguards Systemic Metabolic Homeostasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40549483.
- Also identified by DOI 10.2337/db24-0721 and PMC identifier 12365418.
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Abstract
Understanding the role of micropeptides (miPs) in metabolic regulation could enhance insights into metabolic diseases and open new pathways for treatment. Small integral membrane protein 30 (Smim30), an adipose tissue macrophage-expressed miP, maintains insulin sensitivity and safeguards systemic metabolic homeostasis. Smim30 modulates inflammatory responses and macrophage-adipocyte communication in adipose tissue. Smim30 could serve as a potential diagnostic biomarker and therapeutic target for metabolic disorders.
Medical subject headings
- Insulin Resistance
- Adipose Tissue
- Macrophages
- Homeostasis
- Membrane Proteins