Toward a Next-Generation Liquid Biopsy for HPV+ HNSCC: Opportunities, Challenges, and the Road Ahead.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 40552930.
- Also identified by DOI 10.1158/1078-0432.CCR-25-1488 and PMC identifier 12353175.
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Abstract
Human papillomavirus (HPV) whole-genome sequencing-based plasma ctDNA analysis has demonstrated high diagnostic accuracy in identifying HPV-positive head and neck cancer, supporting the potential for future clinical validation through biomarker advancement paradigms. In this issue, we discuss how this research opens exciting future directions for liquid biopsy research and clinical implementation for HPV+ head and neck squamous cell carcinoma. See related article by Bryan et al., p. 3483.
Medical subject headings
- Papillomavirus Infections
- Squamous Cell Carcinoma of Head and Neck
- Biomarkers, Tumor
- Head and Neck Neoplasms