Supramolecular Nanoplatform for Biofilm Eradication and Anti-inflammatory by Phototherapies and Macrophage Repolarization.

Abstract

Biofilm dispersion and persistent inflammation are key challenges in treating bacterial infections. Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), have emerged as promising approaches for treating bacterial infections. However, several challenges continue to impede the treatment effectiveness, particularly, the inevitable inflammatory side effects. Herein, a supramolecular nanoplatform (R-AuSTP-Be) is developed for precise targeting to bacterial infection sites, effective antimicrobial and anti-inflammatory for infected wound healing. R-AuSTP-Be can neutralize bacterial exotoxins for remodeling bacteria microenvironment, and disperse biofilms by precise phototherapies with dual-mode bacteria targeting by glycoprotein covalent bonding and electrostatic attraction. Meanwhile, R-AuSTP-Be reshapes the inflammatory environment by down-regulating M1 macrophage expression and up-regulating M2 macrophage expression. The excellent antibacterial and anti-inflammatory effects of R-AuSTP-Be provide a competitive strategy for treating bacterial infectious diseases.