Systematic profiling reveals betaine as an exercise mimetic for geroprotection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40570836.
- Also identified by DOI 10.1016/j.cell.2025.06.001.
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Abstract
Exercise has well-established health benefits, yet its molecular underpinnings remain incompletely understood. We conducted an integrated multi-omics analysis to compare the effects of acute vs. long-term exercise in healthy males. Acute exercise induced transient responses, whereas repeated exercise triggered adaptive changes, notably reducing cellular senescence and inflammation and enhancing betaine metabolism. Exercise-driven betaine enrichment, partly mediated by renal biosynthesis, exerts geroprotective effects and rescues age-related health decline in mice. Betaine binds to and inhibits TANK-binding kinase 1 (TBK1), retarding the kinetics of aging. These findings systematically elucidate the molecular benefits of exercise and position betaine as an exercise mimetic for healthy aging.
Medical subject headings
- Betaine
- Physical Conditioning, Animal
- Aging