Atopic Dermatitis With Comorbid Skin Diseases: Recognition and Successful Treatment.

Sani, Sonam; Flohr, Carsten; Abuabara, Katrina; Singh, Anne Marie; Yip, Alphonsus; Mackenzie, Madelynn; Fonacier, Luz · J Allergy Clin Immunol Pract · 2025

review · Level V

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Abstract

Atopic dermatitis (AD) is a common, chronic inflammatory skin disease that affects both children and adults. Atopic dermatitis is characterized by pruritus, erythema, induration, and scale, which can present with other conditions that may mimic or complicate AD; often leading to diagnostic challenges. Differential diagnoses include seborrheic dermatitis, contact dermatitis, psoriasis, infections, inflammatory/autoimmune disorders, cutaneous T-cell lymphoma, and immunodeficiency-related dermatoses; to name a few. This review article focuses on AD and its associated cutaneous comorbid diseases. Familiarity with the spectrum of these diseases and their distinguishing features is crucial for diagnostic accuracy and to optimize patient management.

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