ATROPHY GROWTH RATES IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION COMPARED WITH FELLOW EYES WITH DRY AGE-RELATED MACULAR DEGENERATION.

Abstract

To study the natural history and anatomical characteristics of geographic atrophy in eyes with dry age-related macular degeneration (dAMD) compared with fellow eyes with macular atrophy and concurrent neovascular AMD (nAMD) treated with anti-vascular endothelial growth factor injections. This is a single-center, retrospective chart review. Data were recorded at two time points (#1 and #2) one year apart. Two independent graders reviewed the images to measure atrophy area and grade it based on the Consensus on Atrophy Meeting group criteria. Difference in atrophy area between the two time points was calculated. A square root transformation was also performed to report the change in atrophy progression. Two hundred eight eyes of 104 patients were included: 104 eyes had dAMD and 104 fellow eyes had nAMD. The mean (SD) atrophy area was 14.05 (9.96) mm 2 in dAMD eyes and 14.14 (9.26) mm 2 in nAMD eyes ( P = 0.95) at time point #1, and 16.92 (10.83) mm 2 in dAMD eyes and 17.35 (11.03) mm 2 in nAMD eyes ( P = 0.78) at time point #2. The mean (SD) atrophy growth rate was 3.08 (2.52) mm 2 /year in the nAMD eyes and 2.77 (1.88) mm 2 /year in the dAMD eyes ( P = 0.32). Using the square root transformation, the growth rates were 0.40 (0.24) mm/year in nAMD and 0.38 (0.22) mm/year in dAMD ( P = 0.55). Geographic atrophy in eyes with dAMD and macular atrophy in fellow eyes with nAMD exhibit similar growth rates, suggesting a high degree of concordance and potentially a similar mechanism of atrophy development and progression.