Virtual Cell Challenge: Toward a Turing test for the virtual cell.

Roohani, Yusuf H; Hua, Tony J; Tung, Po-Yuan; Bounds, Lexi R; Yu, Feiqiao B; Dobin, Alexander; Teyssier, Noam; Adduri, Abhinav et al. · Cell · 2025

basic_science · Level V

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Abstract

Virtual cells are an emerging frontier at the intersection of artificial intelligence and biology. A key goal of these cell state models is predicting cellular responses to perturbations. The Virtual Cell Challenge is being established to catalyze progress toward this goal. This recurring and open benchmark competition from the Arc Institute will provide an evaluation framework, purpose-built datasets, and a venue for accelerating model development.

Medical subject headings