Comprehensive profiling of the mutational landscape of hidradenoma papilliferum validates key role of alterations in the phosphoinositide 3-kinase/AKT pathway.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40580495.
- Also identified by DOI 10.1093/bjd/ljaf257 and PMC identifier 12532136.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Comprehensive characterization of the mutational landscape of hidradenoma papilliferum (HP) identified <i>PIK3CA</i> and <i>PIK3R1</i> as mutually exclusive driver genes. Taken together with the mutation of other genes involved in phosphoinositide 3-kinase/AKT signalling, our findings confirm a key role of the alteration of this pathway in the pathogenesis of HP. The absence of a significant presence of human papillomavirus (HPV) sequences suggests that HPV is not involved in the aetiology of HP.