Enhancing Nasopharyngeal Cancer Follow-up: 68 Ga-Trivehexin PET/CT for Distinguishing Recurrence From Infection.

Denizmen Zorba, Dilara; Isik, Emine Goknur; Arslan, Dilsat Firat; Sen, Comert; Kuyumcu, Serkan · Clin Nucl Med · 2026

case_report · Level V

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Abstract

The role of 18 F-FDG PET/CT (FDG) in detecting recurrence of nasopharyngeal squamous cell carcinoma (NFSCC) is undeniably high; however, hypermetabolism due to infection/inflammation can lead to false-positive interpretation. 68 Ga-Trivehexin PET/CT (TRV-PET), a new PET imaging agent used to visualize αVβ6 integrin receptors, has shown promising results in overcoming false-positive FDG uptake in lymph node metastases in head and neck tumors. This case report compares the findings of 68 Ga-Trivehexin PET/CT with 18 F-FDG PET/CT, 99m Tc-MDP bone scintigraphy (BS), and 99m Tc-HMPAO labeled leukocyte scintigraphy (LLS) in the differential diagnosis of local recurrence/infection in a patient with a history of NFSCC.

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