The NARly side of whole-body NAD homeostasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40602367.
- Also identified by DOI 10.1016/j.cmet.2025.06.003.
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Abstract
Nicotinic acid riboside (NAR), one of two nucleoside precursors of nicotinamide adenine dinucleotide (NAD) coenzymes, is revealed to function in systemic NAD homeostasis. By knocking out Nmnat1 in liver, investigators discovered a liver-to-kidney NAR transit pathway and learned that kidney can be a donor in addition to a receiver of NAD precursors.
Medical subject headings
- Homeostasis
- NAD
- Niacinamide