VAMP8 Is an Endosomal v-SNARE That Supports GLP-1 Receptor Recycling in Pancreatic β-Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40608311.
- Also identified by DOI 10.2337/db24-0921 and PMC identifier 12365419.
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Abstract
Vesicle-associated membrane protein 8 (VAMP8) localizes to endosomal vesicles and mediates their exocytosis in pancreatic β-cells. VAMP8-dependent vesicle fusion delivers glucagon-like peptide 1 receptor and GLUT2 to the plasma membrane. VAMP8 overexpression inhibits insulin granule exocytosis. "Newcomer" exocytosis likely involves endosomal compartments, not insulin granules.
Medical subject headings
- Insulin-Secreting Cells
- R-SNARE Proteins
- Endosomes
- Glucagon-Like Peptide-1 Receptor