Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn's disease using single-cell and spatial multi-omics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40608410.
- Also identified by DOI 10.1172/JCI193413 and PMC identifier 12404762.
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Abstract
Up to 40% patients with Crohn's disease suffer from perianal disease, a debilitating complication with unclear etiology. This study identified unique pathophysiology which may help develop novel therapies.
Medical subject headings
- Crohn Disease
- Rectal Fistula
- Interferon-gamma
- Single-Cell Analysis
- Signal Transduction