Toward building kidney organoids with plumbing: Fusion of nephron with ureteric bud.

Zhang, Chao; Xia, Yun · Cell Stem Cell · 2025

basic_science · Level V

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Abstract

The fusion of distal nephron and ureteric bud represents a critical developmental milestone required for establishing a functional kidney plumbing system. In this issue of Cell Stem Cell, Shi et al.<sup>1</sup> report a protocol for generating human kidney organoids with an integrated collecting system by recapitulating this key developmental fusion event.

Medical subject headings