From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40614713.
- Also identified by DOI 10.1016/j.stem.2025.06.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hematopoietic stem cells (HSCs) with mutations that can cause clonal hematopoiesis of indeterminate potential (CHIP) accumulate during aging. Agarwal et al.<sup>1</sup> demonstrate in Nature that intestinal barrier permeability increases with age and enables the microbial metabolite ADP-heptose to reach the bone marrow, thus driving the expansion of DNMT3A-mutant HSCs.
Medical subject headings
- Gastrointestinal Microbiome
- Hematopoietic Stem Cells
- Clonal Hematopoiesis