Axillary Management for Patients Undergoing Total Mastectomy and a Positive Sentinel Lymph Node: Is Axillary Dissection Necessary?

Abstract

We sought to evaluate whether patients with breast cancer who undergo a total mastectomy (TM) can safely forgo a completion axillary lymph node dissection (cALND) in the presence of one to three positive sentinel lymph nodes (SLN+). A multicenter retrospective cohort study (2012-2022) was conducted in patients with cT1-3cN0 who underwent TM with 1-3 SLN+ compared by cALND versus. no further surgery. We compared overall survival (OS) and locoregional recurrence rates (LRR) and investigated whether the omission of cALND altered adjuvant treatment. In total, the study included 139 patients with SLN+TM, with a mean tumor size of 19.44 mm (SD:10.64); 76% (n = 105) of these patients underwent SLNB-alone. Patients treated by cALND had a younger mean age than those treated by SLNB-alone (49.5 vs. 56 years and p = 0.016). Patients undergoing cALND were more likely to have macrometastatic disease (97% vs. 65% and p < 0.001) and extranodal extension (47% vs. 29% and p = 0.046). cALND was associated with higher rates of adjuvant chemotherapy (88% vs. 62% and p = 0.004). Postmastectomy radiotherapy (PMRT) was similar between groups (79% vs. 82% and p = 0.68). At a mean follow-up of 5.2 years, there was one chest-wall LRR in the SLNB group, with no axillary recurrences. LRR did not significantly differ with or without cALND (2.9% vs. 1.0% and p = 0.4). Five-year overall survival rates were similar between groups (100% vs. 94% and p = 0.2). We found high OS and low LRR among patients undergoing upfront TM with 1-3 SLN+ without cALND. Completion ALND did not decrease receipt of PMRT but was associated with higher rates of adjuvant chemotherapy. Our findings support the omission of cALND after TM for patients with 1-3 SLN+.