99m Tc-PYP and 99m Tc-MDP Scintigraphy in a Rare Case of Combined ApoA-I Cardiac Amyloidosis and Paget Disease of the Bone.
case_report · Level V
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- Record sourced from PubMed, PMID 40623125.
- Also identified by DOI 10.1097/RLU.0000000000005879.
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Abstract
A 70-year-old man with a 20-year history of heart failure developed atrial fibrillation and underwent pacemaker implantation; however, his heart failure continued to worsen. Imaging with 99m Tc-PYP scintigraphy revealed significant uptake in the myocardium and the right pelvic bone. Similarly, 99m Tc-methylene diphosphonate scintigraphy demonstrated positive uptake in both regions. A myocardial biopsy confirmed cardiac amyloidosis, and mass spectrometry identified ApoA-I amyloidosis. In addition, a bone biopsy of the right iliac wing resulted in a pathologic diagnosis of Paget disease of bone.
Medical subject headings
- Technetium Tc 99m Medronate
- Osteitis Deformans
- Amyloidosis
- Technetium Tc 99m Pyrophosphate