BEAST X for Bayesian phylogenetic, phylogeographic and phylodynamic inference.

Baele, Guy; Ji, Xiang; Hassler, Gabriel W; McCrone, John T; Shao, Yucai; Zhang, Zhenyu; Holbrook, Andrew J; Lemey, Philippe et al. · Nat Methods · 2025

basic_science · Level V

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Abstract

Here we present the open-source and cross-platform BEAST X software that combines molecular phylogenetic reconstruction with complex trait evolution, divergence-time dating and coalescent demographics in an efficient statistical inference engine. BEAST X significantly advances the flexibility and scalability of evolutionary models supported. Novel clock and substitution models leverage a large variety of evolutionary processes; discrete, continuous and mixed traits with missingness and measurement errors; and fast, gradient-informed integration techniques that rapidly traverse high-dimensional parameter spaces.

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