Modifications of microbiome-derived cell-free RNA in plasma discriminates colorectal cancer samples.
basic_science · Level V
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- Record sourced from PubMed, PMID 40629040.
- Also identified by DOI 10.1038/s41587-025-02731-8.
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Abstract
Circulating cell-free RNA (cfRNA) in plasma represents a promising avenue for cancer detection. We report low-input multiple methylation sequencing, a method for profiling modification patterns in cfRNA, enabling the detection of diverse transfer RNAs and small noncoding RNAs derived from both the human genome and the microbiome. RNA modification patterns in microbiome-derived cfRNA accurately reflect host microbiota activity and hold potential for the early detection of colorectal cancer.