Autonomous bioluminescence emission from transgenic mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40632853.
- Also identified by DOI 10.1126/sciadv.ads0463 and PMC identifier 12239958.
- Licence recorded as CC BY-NC.
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Abstract
The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here, we report the generation of an autobioluminescent transgenic mouse line constitutively expressing the genes of the bacterial bioluminescence system, enabling substrate-free in vivo luminescence imaging of a living mammal.
Medical subject headings
- Luminescent Measurements
- Luminescence