Revealing Cerebral Microvascular Changes in Diabetic Rodents With Ultrasound Localization Microscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40633096.
- Also identified by DOI 10.2337/db25-0007.
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Abstract
Cerebral microvascular disease can be triggered in people with diabetes who have chronic hyperglycemia. The aim of our study was to understand what effect diabetes has on the cerebral vasculature. In a rodent model, diabetes caused varying degrees of reduced cerebral vascular density and slowed cerebral blood flow in the brain striatum, basal forebrain, thalamus, hypothalamus, and hippocampus. There is a correlation between vessel density and blood flow velocity and the correlation changes in the diabetic state.
Medical subject headings
- Diabetes Mellitus, Experimental
- Cerebrovascular Circulation
- Microvessels
- Brain